MYELOID NEOPLASIA Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells
نویسندگان
چکیده
Florian Kuchenbauer,1-3 Sarah M. Mah,3 Michael Heuser,4 Andrew McPherson,5 Jens Rüschmann,3 Arefeh Rouhi,2 Tobias Berg,3 Lars Bullinger,1 Bob Argiropoulos,3 Ryan D. Morin,5 David Lai,3 Daniel T. Starczynowski,3 Aly Karsan,3 Connie J. Eaves,3 Akira Watahiki,6 Yuzhuo Wang,6 Samuel A. Aparicio,7 Arnold Ganser,4 Jürgen Krauter,4 Hartmut Döhner,1 Konstanze Döhner,1 Marco A. Marra,5 Fernando D. Camargo,8 Lars Palmqvist,9 Christian Buske,2 and R. Keith Humphries3
منابع مشابه
Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells.
Processing of pre-miRNA through Dicer1 generates an miRNA duplex that consists of an miRNA and miRNA* strand. Despite the general view that miRNA*s have no functional role, we further investigated miRNA* species in 10 deep-sequencing libraries from mouse and human tissue. Comparisons of miRNA/miRNA* ratios across the miRNA sequence libraries revealed that 50% of the investigated miRNA duplexes ...
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